In Highschool Quizbowl, I'd take advantage of the fact that most untrained readers have a hard time stopping mid-syllable, or even mid-word, so any time there was a question that hinged on a single word, such as a world capital question, I'd buzz in on the first letter of the word, and they'd usually get out 2 syllables before stopping, providing enough information.

Q: What is the capital of L-(BUZZ)-ithu-- [stops reading].

A. Vilnius.

But if they had had really good reaction time and stopped on L--, I'd have been hosed. Latvia, Lithuania, Liechtenstein, Libya, Liberia, etc...