The study says: "Randomized controlled trials, however, have shown variable results or even possible harm [10,11,12]. Moreover, current guidelines and a Bayesian re-analysis of a previous trial have led to recommendations not to use intravenous vitamin C in patients with sepsis because of possible harm [13, 14]. Regrettably, these studies used ascorbic acid, a compound associated with the induction of metabolic acidosis and acidemia [15]. This makes it uncertain whether the unclear effects in human sepsis were due to the administration of a suboptimal preparation of the study medication. In contrast, sodium ascorbate (NaAscorbate) has a physiological pH, does not contribute to acidosis, can be given at a much greater dose, and may carry a different efficacy profile [16]."

https://ccforum.biomedcentral.com/articles/10.1186/s13054-02...