I think we probably place too much hope in improving technology, in general.

It's a tremendous breakthrough, I'd say. But rather than focus on the tech, I'd rather see a rethinking of our governmental approach to issues concerning public health and how approval processes are set up. I'd rather focus on how we incentivize breakthroughs on issues that are most important, rather than developing another medicine that's 1% better at treating acne, for example. And I'd rather see cultural changes around adopting already existing technologies -- less than half of folks take flu shots!

I'd argue that getting flu shot numbers way up would be more of a breakthrough than any benefits from mRNA, as incredible as it is. Not that we have to choose one or the other. I'm just saying I'd like these other issues to get more prominence.

My fear is that we still don’t fully understand genetic and epigenetic coding and there are probably latent dangers lurking with this class of vaccines that may not even be apparent until a new generation of posterity.

I suppose there's always a (very) small chance that we're making a civilization-ending mistake with this new vaccine :)

On the flip-side, while COVID can cause serious illness (and death), with a survival rate north of 99%, there's virtually no risk of societal collapse if we do nothing (OTOH, our response to it has been far more de-stabilizing).