I played a ton of Nethack in college and adopted Dvorak at the same time. hjkl work remarkably well with Dvorak, and I found it so much more natural than the same letters with Qwerty.

j and k being next to each other makes their relative motion sensible still. And the new positions of h and l keep them in the correct relative position to indicate left and right, but easier to use. The right index finger is already on h and the pinky needs to move up one key for l. And up/down is now the left hand, with right/left being on the right hand.

I've found emacs to be similarly more sensible and comfortable, using default key bindings, with Dvorak than Qwerty.