The arch linux wiki page [1] is a good place to start (Note you don't have to use arch for the host to get value out of the page, I use nixos), and/or the macos repo [2] (Or maybe this newer one [3])
The only real hurdle hardware wise is your IOMMU groups and your CPU compatibility, if you have a moderately modern system it should be a problem.
I also have a couple of inexpensive PCIe USB cards that I pass through to the guests for direct USB access, highly recommended.
The guides will use qcow2 images or pass through a block device, as I mentioned I have a giant LVM pool, I just create lvs for each vm and pass the volume through to the vm as a disk , and let the vm handle it. In the host you can use kpartx to bind and mount the partitions if you ever need to open them up.
