Mechanistically, there is a large difference between ibuprofen and ketamine. Ibuprofen does not work on the NMDA receptor, as ketamine does. NMDA activity modulation is associated with psychological phenomena:
"""NMDA receptor antagonists can mimic these problems; they sometimes induce "psychotomimetic" side effects, symptoms resembling psychosis. Such side effects caused by NMDA receptor inhibitors include hallucinations, paranoid delusions, confusion, difficulty concentrating, agitation, alterations in mood, nightmares, catatonia,;ataxia, anesthesia, and learning and memory deficits.""" (From Wikipedia)
Ibuprofen hits the COX enzymes, for which no psychological effects are noted.
Edit: of course I'm not discounting your own observations, just regurgitating some textbook knowledge.
"""NMDA receptor antagonists can mimic these problems; they sometimes induce "psychotomimetic" side effects, symptoms resembling psychosis. Such side effects caused by NMDA receptor inhibitors include hallucinations, paranoid delusions, confusion, difficulty concentrating, agitation, alterations in mood, nightmares, catatonia,;ataxia, anesthesia, and learning and memory deficits.""" (From Wikipedia)
Ibuprofen hits the COX enzymes, for which no psychological effects are noted.
Edit: of course I'm not discounting your own observations, just regurgitating some textbook knowledge.