Right hand on mouse, left hand on WASD. The spacebar is always easy to hit your thumb, but you have to move your right hand away the mouse to hit Page Down. Plus it mixes well with Vimperator-like extensions, to the point that I can do 90% of my browsing with one hand.
EDIT: and before anyone points out that if I'm already using extensions I could easily add another, yes and I would if I had to, but it's not ideal, because 1. Extensions crash, fail to load, or aren't allowed by internal browser pages, and 2. You sometimes have to use other peoples' machines and it's annoying when basic functionality is locked away.
EDIT: and before anyone points out that if I'm already using extensions I could easily add another, yes and I would if I had to, but it's not ideal, because 1. Extensions crash, fail to load, or aren't allowed by internal browser pages, and 2. You sometimes have to use other peoples' machines and it's annoying when basic functionality is locked away.